Effects of LY354740, a selective agonist of Glutamate metabotropic group II receptors, on aggressive behavior in mice
Recent studies have demonstrated that glutamate metabotropic receptors mGlu1 and mGlu5 are involved in the regulation of aggressive behaviour. This study examines the effect of the administration of LY354740 (4-16 mg/kg i.p.), a selective group II metabotropic receptors agonist (mGlu2/3), using an i...
| Autor Principal: | De Castro, Vanessa; Universidad de Málaga |
|---|---|
| Otros Autores: | Martín-López, Mercedes; Universidad de Málaga, Navarro, José Francisco; Universidad de Málaga |
| Formato: | info:eu-repo/semantics/article |
| Idioma: | spa |
| Publicado: |
Pontificia Universidad Javeriana
2010
|
| Materias: | |
| Acceso en línea: |
http://revistas.javeriana.edu.co/index.php/revPsycho/article/view/821 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| Sumario: |
Recent studies have demonstrated that glutamate metabotropic receptors mGlu1 and mGlu5 are involved in the regulation of aggressive behaviour. This study examines the effect of the administration of LY354740 (4-16 mg/kg i.p.), a selective group II metabotropic receptors agonist (mGlu2/3), using an isolation-induced aggression model. Individually housed mice were exposed to anosmic opponents 30 min after drug administration. Ten min of diadic interactions were staged between a singly housed and an anosmic mouse in a neutral area. The encounters were videotaped and the accumulated time allocated by subjects to ten broad behavioural categories was estimated using an ethologically based analysis. LY354740 (12 and 16 mg/kg) significantly reduced offensive behaviours, without affecting immobility, as compared with the control group. These results suggest an implication of mGlu group II receptors in the modulation of aggression |
|---|