Cytokeratin 19, p63 and CD56 in Assessing Papillary Thyroid Carcinoma when the Morphology is not Clear: Experience at the Hospital Universitario San Ignacio
Papillary carcinoma of the thyroid (PC) is diagnosed in most of the cases only by H&E morphology; however, the diagnosis in some cases became quite difficult, and the lesion can be over-called, for example, when the lesion has a capsule or when there are florid hyperplastic changes in goiter...
| Autor Principal: | Bolívar, Isabel C.; Pontificia Universidad Javeriana |
|---|---|
| Otros Autores: | Rodríguez, Jorge L.; Pontificia Universidad Javeriana, Jaramillo García, Luis Fernando; Pontificia Universidad Javeriana-Hospital Universitario San Ignacio, Mejía, Maddy; Pontificia Universidad Javeriana-Hospital Universitario San Ignacio |
| Formato: | info:eu-repo/semantics/article |
| Idioma: | spa |
| Publicado: |
Pontificia Universidad Javeriana
2013
|
| Materias: | |
| Acceso en línea: |
http://revistas.javeriana.edu.co/index.php/vnimedica/article/view/16204 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| Sumario: |
Papillary carcinoma of the thyroid (PC) is diagnosed in most of the cases only by H&E morphology; however, the diagnosis in some cases became quite difficult, and the lesion can be over-called, for example, when the lesion has a capsule or when there are florid hyperplastic changes in goiter. And it is well known that a misdiagnosis of a PC can bring important clinical consequences. Studies have showed that immunohistochemistry can be helpful in those cases, however several markers have been proposed. We assessed expression of three marker proposed in other study (CK19, CD56 and p63) in PC and non-papillary lesions, neoplastic and non-neoplastic. 29 cases of PC were included and 31 cases on non-papillary lesions 96 % of PC were strongly positive for CK19, and 90 % were CD56 negative. Only 64 % of all PC shower focal positivity for p63. 100 % of the cases of nonpapillary lesion were strongly positive for CD56 and negative for CK19. With these results, we were able to confirm previous findings about the use of CK19 and CD56 could be useful in the cases of PC when the morphology on H&E is doubtful. |
|---|