Low HLA polymorphism in Colombian mestizos
Objective: This paper aims to describe the allele frequency and haplotype of HLA class I and II molecules in a Colombian mestizo population.Methodology: HLA class I and II molecules on 197 unrelated Colombian individuals and 157 unrelated individuals making up 53 families fromdifferent regions of th...
| Autor Principal: | Ávila-Portillo, Luz Mabel; Instituto de Referencia Andino S.A.; Hospital Militar Central |
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| Otros Autores: | Carmona, Alejandra; Universidad Católica de Manizales, Franco, Leidy; Instituto de Referencia Andino S.A., Briceño, Ignacio; Pontificia Universidad Javeriana, Casas, María Consuelo; Instituto de Referencia Andino S.A., Gómez, Alverto; Instituto de Referencia Andino S.A.; Pontificia Universidad Javeriana |
| Formato: | info:eu-repo/semantics/article |
| Idioma: | spa |
| Publicado: |
Pontificia Universidad Javeriana
2010
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| Materias: | |
| Acceso en línea: |
http://revistas.javeriana.edu.co/index.php/vnimedica/article/view/16020 |
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| Sumario: |
Objective: This paper aims to describe the allele frequency and haplotype of HLA class I and II molecules in a Colombian mestizo population.Methodology: HLA class I and II molecules on 197 unrelated Colombian individuals and 157 unrelated individuals making up 53 families fromdifferent regions of the country were studied at the Immunology Laboratory at the Military Hospital Central of Bogotá and at the Instituto de ReferenciaAndino by the PCR-SSP method.Results: The haplotype HLA-A * 24 B*35 DR*04 was the most common, which is consistent with other studies carried out in Colombian mestizos.Conclusions: The Hardy-Weinberg disequilibrium found in the population analyzed in this study should alert on a possible reduction of the immuneresponse repertoire in Colombia, which could be the origin of a consequent fragility of the population in face of new infections that could eventuallybecome epidemic. |
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