Hepcidin: Interaction with Hemojuvelin and its Contribution in the Diagnosis of Diseases Related to Iron Metabolism
The hepcidin is a peptide hormone produced by the liver with anti-bacterial activity, is involved in regulation iron metabolism, making it possible to use it as another parameter to assess some entities related to disorders associated with iron metabolism. Hepcidin regulates intestinal absorption of...
| Autor Principal: | Esquiva Mercado, María Claudia; Universidad de Antioquia |
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| Otros Autores: | Acevedo Toro, Paola Andrea; Universidad de Antioquia |
| Formato: | info:eu-repo/semantics/article |
| Idioma: | spa |
| Publicado: |
Pontificia Universidad Javeriana
2012
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| Materias: | |
| Acceso en línea: |
http://revistas.javeriana.edu.co/index.php/vnimedica/article/view/16163 |
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| Sumario: |
The hepcidin is a peptide hormone produced by the liver with anti-bacterial activity, is involved in regulation iron metabolism, making it possible to use it as another parameter to assess some entities related to disorders associated with iron metabolism. Hepcidin regulates intestinal absorption of iron level and the role of ferroportin in the cell, preventing either iron overload or iron consumption reserve, this is turn regulating for inflammatory stimuli, iron store, erythropoietic activity and signaling patway SMAD,STAT and JAK; in this signaling patway involved a membrane protein called hemojuvelin. The hemojuvelin acts as a bone morphogenetic protein co-receptor, they induce hepcidin gene transcription through the SMAD1/5/8-SMAD4. Because of the associations of hemojuveline with hepcidin expression and the relationship of the latter with inflammatory processes and regulations of iron metabolism have been proposed some techniques for the determination of both proteins as Elisa, Dotblot, Immunoassays and SELDI-TOF MS. |
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