Effect of Calendula officinalis on the Proliferation of Human Gingival Fibroblast
Background: Calendula officinalis has multiple therapeutic properties such as improving the process of cicatrization. Therefore, it is interesting its possible value and use to treat oral pathologies. Objective: To observe the effect of three presentations of C. officinalis in different concentratio...
| Autor Principal: | Madrid Ahumada, María Alejandra; Pontificia Universidad Javeriana |
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| Otros Autores: | Mahecha Donato, Luis Carlos; Pontificia Universidad Javeriana, Oviedo Peñaloza, Viviana Andrea; Pontificia Universidad Javeriana, Chaves Clavijo, Margarita; Pontificia Universidad Javeriana, Roa Molina, Nelly Stella; Pontificia Universidad Javeriana / Universidad Nacional Autónoma de México, García Robayo, Dabeiba Adriana; Universidad Nacional de Colombia, Moreno Abello, Gloria Cristina; Pontificia Universidad Javeriana |
| Formato: | info:eu-repo/semantics/article |
| Idioma: | spa |
| Publicado: |
Editorial Pontificia Universidad Javeriana
2010
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| Acceso en línea: |
http://revistas.javeriana.edu.co/index.php/revUnivOdontologica/article/view/1030 |
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| Sumario: |
Background: Calendula officinalis has multiple therapeutic properties such as improving the process of cicatrization. Therefore, it is interesting its possible value and use to treat oral pathologies. Objective: To observe the effect of three presentations of C. officinalis in different concentrations on the proliferation of the human gingival fibroblasts. Methods: Human Gingival Fibroblasts (FGH) in fifth pass were obtained from healthy donor explants and exposed to stimuli with ethanolic extract of C. officinalis (EEC), tincture of C. officinalis (TC) and K-Trix® rinsing in concentrations of 750, 500, 150, 100 μg/ml. Proliferation of the FGH was observed at 12, 24 and 48 hours in relation with a group of cells without getting any stimulation, using the MTA test with Cell Titer 96®. Results: The major proliferative effect was achieved by the EEC in concentrations of 750 and 500 μg/ml at 12 hours. The tincture of 100 and 150 μg/ml C. officinalis at 48 hours generated inhibition in cell growth whereas the rinsing K-Trix® did not have effect on the proliferation of the FGH in any concentration at any time. Conclusion: The proliferation of the FGH depends on the presentation of the C. officinalis, time, and concentration. |
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