Effects of intrahypocampal administration of the BLMP-101 peptide on a spatial memory task in Wistar rats
The BLMP-101 peptide has the potential features to treat memory deficiency. The herein research aimed at corroborating the results obtained in previous researches and tests conducted on the effectiveness of the peptide BLMP-101 designed by the Computational and Structural Biochemestry Unit of the Po...
| Autor Principal: | Lareo, Leonardo; Pontificia Universidad Javeriana, Bogotá |
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| Otros Autores: | Bríñez Horta, José Arturo; Pontificia Universidad Javeriana, Bogotá, Oyuela Vargas, Raúl, Albarracín, Sonia, León, Laura Andrea; Pontificia Universidad Javeriana, Bogotá, Cárdenas P., Fernando; Universidad de los Andes |
| Formato: | info:eu-repo/semantics/article |
| Idioma: | spa |
| Publicado: |
Pontificia Universidad Javeriana
2010
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| Materias: | |
| Acceso en línea: |
http://revistas.javeriana.edu.co/index.php/revPsycho/article/view/822 |
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| Sumario: |
The BLMP-101 peptide has the potential features to treat memory deficiency. The herein research aimed at corroborating the results obtained in previous researches and tests conducted on the effectiveness of the peptide BLMP-101 designed by the Computational and Structural Biochemestry Unit of the Pontificia Universidad Javeriana, Colombia. However, and unlike previous researches, the objective of this paper measured the effectiveness of the BLMP-101 peptide, when supplied in different dozes and through intrahipocampal application to confirm its effects to facilitate spatial memory. 31 Wistar rats were used into 4 different groups: three treatment groups and one control group. The control group was infused with saline solution, and one of the treatment groups was infused with NMDA, while the other two experimental groups were infused with different dozes of the BLMP-101peptide (0.3, 3.0 ug/ul). Results suggest that the BLMP-101 peptide, when supplied in 3.0 ug/ul, facilitates spatial memory showing better results than the NMDA |
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