Elevated systemic inflammatory burden and cardiovascular risk in young adults with endodontic apical lesions
Introduction: The aim of this study was to assess whether apical lesions are associated with inflammatory serum markers of cardiovascular risk, especially highsensitivity C-reactive protein (hsCRP), in young adults. Methods: In this cross-sectional study, otherwise healthy individuals with apic...
| Autor Principal: | Garrido, Mauricio |
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| Otros Autores: | Cárdenas, Angélica M., Astorga, Jessica, Quinlan, Francisca, Valdés, Macarena, Chaparro, Alejandra, Carvajal, Paola, Pirkko, Pussinen, Huamán-Chipana, Patricia, Jalil, Jorge E., Hernández, Marcela |
| Formato: | Generación de Nuevo Conocimiento: Artículos publicados en revistas especializadas - Electrónicos |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: |
Garrido, M., Cárdenas, Angélica M., Astorga, Jessica., Quinlan, F., Valdés, M., Chaparro, A., Carvajal, P., . . . Hernández, M. (2019). Elevated systemic inflammatory burden and cardiovascular risk in young adults with endodontic apical lesions. Bogotá: doi:10.1016/j.joen.2018.11.014 |
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| Sumario: |
Introduction: The aim of this study was to assess
whether apical lesions are associated with inflammatory
serum markers of cardiovascular risk, especially highsensitivity
C-reactive protein (hsCRP), in young adults.
Methods: In this cross-sectional study, otherwise healthy
individuals with apical lesions of endodontic origin
(ALEOs) and a clinical diagnosis of asymptomatic apical
periodontitis and controls aged between 18 and 40 years
were included. Patients’ sociodemographic characteristics,
medical history, and classic cardiovascular risk factors
were recorded, and the pathobiological
determinants of atherosclerosis in youth score was calculated.
Oral clinical and radiographic examinations were
performed. Blood samples were collected to determine
the lipid profile, glycated hemoglobin, hsCRP, immunoglobulin
G, interleukin (IL)-6, IL-10, IL-12p70, matrix metalloproteinase
8, soluble vascular cellular adhesion
molecule-1, soluble intercellular adhesion molecule-1,
and soluble E-selectin. Bivariate and multivariate analyses
adjusting for oral and classic cardiovascular risk factors
were performed. Results: hsCRP levels were
significantly higher in ALEO patients versus controls (median
= 2.54 vs 0.78), whereas the pathobiological determinants
of atherosclerosis in youth score was comparable
among the groups. Also, the levels of IL-6, matrix metalloproteinase
8, and soluble E-selectin were significantly
higher in ALEO patients. hsCRP, IL-6, and IL-12 correlated
with soluble adhesionmolecules. Bivariate analysis based
on hsCRP serum concentrations $1 mg/L showed an
odds ratio (OR) = 6.8, and the risk increased 3.3 times
for an additional ALEO. In multivariate analysis, ALEO
was significantly associated with hsCRP levels $1 mg/L
(OR = 5.1–12.8) independently of the adjustment model. ALEO also associated with
CRP levels >3 mg/L, which was significant after the adjustment for covariates (OR =
4.0). Conclusions: ALEO is associated with the systemic inflammatory burden and cardiovascular
risk determined by hsCRP, supporting a mechanistic link for cardiovascular diseases
in young adults. (J Endod 2019;45:111–115) |
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