Análisis de la expresión de los genes NOS2/Arg1 en macrófagos alveolares durante la infección con strongyloides venezuelensis y por efecto de la administración de inulina 5 % (p/v) EN Rattus norvegicus.
Strongyloidiasis is an asymptomatic disease caused by one helminth called Strongyloides stercoralis. It´s evident in patients as gastric and respiratory insufficiency. It has been reported in something cases in vulnerable population as: childrens, pregnant women, elderly and immunosuppressed patient...
| Autor Principal: | Mena Pacheco, Andrés Sebastián |
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| Formato: | bachelorThesis |
| Idioma: | spa |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: |
http://dspace.ups.edu.ec/handle/123456789/16256 |
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| Sumario: |
Strongyloidiasis is an asymptomatic disease caused by one helminth called Strongyloides stercoralis. It´s evident in patients as gastric and respiratory insufficiency. It has been reported in something cases in vulnerable population as: childrens, pregnant women, elderly and immunosuppressed patients, as absence of participation of interleukins, T helper cells (Th2). Several studies have been proposed to use an inmunomodulators against parasitic, although larvae migration detection and activation of phagocytic cells and lymphocytes.
In the present study, it was evaluated immunomodulator effect of inulin in gene expression of NOS2/Arg1 in alveolar macrophages although Real Time PCR in Wistar rats infected by Strongyloides venezuelensis.
It demonstrated that inulin 5 % (w/v) administration in the host, it protected against parasite infection because of alveolar macrophages to detected Arg1 trough Real Time PCR, it has been showed the response Th2 activation, decrease arbitrary scores of inflammation in lung compartment to generate a homeostasis in cell to cell signal to M1/M2 immune response and contributed to helminth expulsion. |
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