PREVENTION OF ORAL MUCOSITIS IN CANCER PATIENTS WITH ANTINEOPLASIC TREATMENT: A SYSTEMATIC REVIEW
Objective: To evaluate the effectiveness of interventions for the prevention of oral mucositis in cancer patients antineoplasic treated.Methods: The Cochrane Oral Health Group Trials Register, MEDLINE LILACS y SCIELO were searched. Randomized clinical trials were selected. The preventive measures mu...
| Autor Principal: | Otero Wandurraga, Johanna Alejandra; Observatorio de Salud Pública de Santander |
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| Otros Autores: | Torres Pinzón, Harold; U. El Bosque, Pedraza Flechas, Ana María; Instituto Carlos III, González Vélez, Abel Ernesto; Instituto Carlos III |
| Formato: | info:eu-repo/semantics/article |
| Idioma: | spa |
| Publicado: |
Universidad Santo Tomás Seccional Bucaramanga
2011
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| Materias: | |
| Acceso en línea: |
http://revistas.ustabuca.edu.co/index.php/USTASALUD_ODONTOLOGIA/article/view/1146 |
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| Sumario: |
Objective: To evaluate the effectiveness of interventions for the prevention of oral mucositis in cancer patients antineoplasic treated.Methods: The Cochrane Oral Health Group Trials Register, MEDLINE LILACS y SCIELO were searched. Randomized clinical trials were selected. The preventive measures must have been begun the first day of the antineoplasic treatment. Only were include the studies publish in the last 10 years. Review the title and abstract of each result of the search and extracted the outcome measures and results in duplicate. Meta-analysis was performed when two or more studies use the same intervention and was comparable. The statistical analysis was made by EPIDAT y RevMan 5.Results: Forty six studies were eligible, 24 were excluded. Fifteen interventions were evaluated, of the included interventions in this study nine showed evidence of some benefit for either preventing or reducing the severity of mucositis, three interventions were present in more than one study and comparable for performing meta-analysis: amifostine, laser He/Ne y zinc. The meta-analysis of zinc was the only one that showed beneficial effect in preventing moderate and severe mucositis.Conclusions: Especially administration of zinc, honey and sucralfate had showed some benefit at preventing or reducing the severity of mucositis associated with cancer treatment. Nevertheless the quality and the sample size of these studies are not enough for recommend and specific intervention instead of another. |
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