Human Prion Diseases
Prions are proteinaceous particles that due to an alteration of its secondary structure on a post-translational process, they can become infectious pathogens responsible for Transmissible Spongiform Encephalopaties (TSEs). The most common TSE in humans is the Creutzfeldt-Jakob Disease (CJD), which c...
| Autor Principal: | Barashi Gozal, Nimrod Shabtai; Pontificia Universidad Javeriana |
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| Otros Autores: | Vargas Acevedo, Catalina; Pontificia Universidad Javeriana, Alfonso Zarco, Luis; Pontificia Universidad Javeriana |
| Formato: | info:eu-repo/semantics/article |
| Idioma: | spa |
| Publicado: |
Pontificia Universidad Javeriana
2013
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| Materias: | |
| Acceso en línea: |
http://revistas.javeriana.edu.co/index.php/vnimedica/article/view/16268 |
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| Sumario: |
Prions are proteinaceous particles that due to an alteration of its secondary structure on a post-translational process, they can become infectious pathogens responsible for Transmissible Spongiform Encephalopaties (TSEs). The most common TSE in humans is the Creutzfeldt-Jakob Disease (CJD), which can be divided into 4 forms according to its cause and its clinico-pathological presentation: Sporadic CJD, Genetic CJD, Iatrogenic CJD and Variant CJD. This disease has an annual incidence of 1 case per million and is manifested as a rapidly progressive dementia in middle-aged and elderly persons. This article presents a systematic review on CJD based on articles published in the past ten years from MedLine and Embase databases |
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