The relevance of glucocorticoid receptor in early stress
Previous studies have shown how Hypothalamic-Pituitary-adrenal Axis dysfunction is related to early life stress; several works show that Hypothalamic-Pituitary-adrenal Axishyperactivity increases production of ACTH and glucocorticoids, indicating a pathophysiological key factor in stress related dis...
| Autor Principal: | Rodríguez Fernández, Jorge Mario; Hospital Universitario San Ignacio |
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| Otros Autores: | García Acero, Mary; Hospital Universitario San Ignacio |
| Formato: | info:eu-repo/semantics/article |
| Idioma: | spa |
| Publicado: |
Pontificia Universidad Javeriana
2010
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| Materias: | |
| Acceso en línea: |
http://revistas.javeriana.edu.co/index.php/vnimedica/article/view/16022 |
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| Sumario: |
Previous studies have shown how Hypothalamic-Pituitary-adrenal Axis dysfunction is related to early life stress; several works show that Hypothalamic-Pituitary-adrenal Axishyperactivity increases production of ACTH and glucocorticoids, indicating a pathophysiological key factor in stress related diseases like depression.This review will discuss results of some epigenetical studies linking early life stress, decreased production of the glucocorticoid receptor and Hypothalamic-Pituitary-adrenal Axis hyperactivity. We conclude how early life stress modulates the expression of the glucocorticoid receptor affecting the development of several brain structures involved in the stress response. |
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