Study protocol for the Maule Cohort (MAUCO) of chronic diseases, Chile 2014–2024
Background: Maule Cohort (MAUCO), a Chilean cohort study, seeks to analyze the natural history of chronic diseases in the agricultural county of Molina (40,000 inhabitants) in the Maule Region, Chile. Molina´s population is of particular interest because in the last few decades it changed from bei...
| Autor Principal: | Huidobro-Muñoz, Andrea |
|---|---|
| Otros Autores: | Silva-Prado, Raúl, Ferreccio, Catterina, Roa, Juan Carlos, Bambs, Claudia, Vives, Alejandra, Corvalán, Alejandro H., Cortés, Sandra, Foerster, Claudia, Acevedo, Johanna, Passi, Alvaro, Toro, Pablo, Covacevich, Yerko, De la Cruz, Rolando, Koshiol, Jill, Olivares, Mauricio, Miquel, Juan Francisco, Cruz, Francisco, Quest, Andrew F., Kogan, Marcelo J., Castro, Pablo F., Lavandero, Sergio |
| Formato: | Artículo |
| Idioma: | English |
| Publicado: |
2017
|
| Materias: | |
| Acceso en línea: |
http://repositorio.ucm.cl:8080/handle/ucm/667 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| Sumario: |
Background: Maule Cohort (MAUCO), a Chilean cohort study, seeks to analyze the natural history of chronic diseases
in the agricultural county of Molina (40,000 inhabitants) in the Maule Region, Chile. Molina´s population is of particular
interest because in the last few decades it changed from being undernourished to suffering excess caloric intake, and
it currently has the highest national rates of cardiovascular diseases, stomach cancer and gallbladder cancer. Between
2009 and 2011 Molina´s poverty rate dropped from 24.1 % to 13.5 % (national average 20.4 %); in this period the
county went from insufficient to almost complete basic sanitation. Despite these advances, chemical pollutants in the
food and air are increasing. Thus, in Molina risk factors typical of both under-developed and developed countries
coexist, generating a unique profile associated with inflammation, oxidative stress and chronic diseases.
Methods/Design: MAUCO is the core project of the recently established Advanced Center for Chronic Diseases
(ACCDiS), Universidad de Chile & Pontificia Universidad Católica de Chile. In this study, we are enrolling and following
10,000 adults aged 38 to 74 years over 10 years. All eligible Molina residents will be enrolled. Participants were
identified through a household census. Consenting individuals answer an epidemiological survey exploring risk factors
(psycho-social, pesticides, diet, alcohol, and physical activity), medical history and physical and cognitive conditions;
provide fasting blood, urine, and saliva samples; receive an electrocardiogram, abdominal ultrasound and bio-impedance
test; and take a hand-grip strength test. These subjects will be re-interviewed after 2, 5 and 7 years. Active surveillance of
health events is in place throughout the regional healthcare system. The MAUCO Bio-Bank will store 30 to 50 aliquots per
subject using an NIH/NCI biorepository system for secure and anonymous linkage of samples with data.
Discussion: MAUCO´s results will help design public health interventions tailored to agricultural populations in Latin
America. |
|---|